Human survival from injury requires an appropriate inflammatory and immune response. We
describe the circulating leukocyte transcriptome after severe trauma and burn injury, as well …

A cornerstone of modern biomedical research is the use of mouse models to explore basic
pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-…

Both increases and decreases in methyl CpG–binding protein 2 (MeCP2) levels cause
neurodevelopmental defects. We found that MeCP2 translation is regulated by microRNA 132 (…

The activity-dependent regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
(AMPA)-type glutamate receptors and the stabilization of synapses are critical to synaptic …

MicroRNAs (miRNAs) regulate cellular fate by controlling the stability or translation of mRNA
transcripts. Although the spatial and temporal patterning of miRNA expression is tightly …

Flexor tendon healing is complicated by adhesions to the surrounding sheath. Transforming
growth factor beta (TGF-β) is a cytokine with numerous activities related to wound healing. …

BACKGROUND: Pediatric trauma involving the bones of the face is associated with severe
injury and disability. Although much is known about the epidemiology of facial fractures in …

The purpose of this study was to perform a systematic review of the existing literature on the
incidence of hypertrophic scarring and the psychosocial impact of burn scars. In a …

Purpose : Case series have shown a Fournier's gangrene mortality rate of 20% to 40% with
an incidence of as high as 88% in some studies. Because to our knowledge there are no …

Objective: To determine patient and injury variables that influence fluid requirements following
burn injury and examine the association between fluid volume received and outcome. …