User profiles for Preston W. Estep
 | Preston EstepHarvard University/Harvard Medical School Verified email at post.harvard.edu Cited by 5330 |
Computational identification of cis-regulatory elements associated with groups of functionally related genes in Saccharomyces cerevisiae
AlignACE is a Gibbs sampling algorithm for identifying motifs that are over-represented in a
set of DNA sequences. When used to search upstream of apparently coregulated genes, …
set of DNA sequences. When used to search upstream of apparently coregulated genes, …
Finding DNA regulatory motifs within unaligned noncoding sequences clustered by whole-genome mRNA quantitation
Whole-genome mRNA quantitation can be used to identify the genes that are most responsive
to environmental or genotypic change. By searching for mutually similar DNA elements …
to environmental or genotypic change. By searching for mutually similar DNA elements …
Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities
…, AA Philippakis, AM Qureshi, FS He, PW Estep III… - Nature …, 2006 - nature.com
Transcription factors (TFs) interact with specific DNA regulatory sequences to control gene
expression throughout myriad cellular processes. However, the DNA binding specificities of …
expression throughout myriad cellular processes. However, the DNA binding specificities of …
A public resource facilitating clinical use of genomes
Rapid advances in DNA sequencing promise to enable new diagnostics and individualized
therapies. Achieving personalized medicine, however, will require extensive research on …
therapies. Achieving personalized medicine, however, will require extensive research on …
[HTML][HTML] Harvard Personal Genome Project: lessons from participatory public research
Background Since its initiation in 2005, the Harvard Personal Genome Project has enrolled
thousands of volunteers interested in publicly sharing their genome, health and trait data. …
thousands of volunteers interested in publicly sharing their genome, health and trait data. …
Selection analyses of insertional mutants using subgenic-resolution arrays
V Badarinarayana, PW Estep III, J Shendure… - Nature …, 2001 - nature.com
We describe a method of genome-wide analysis of quantitative growth phenotypes using
insertional mutagenesis and DNA microarrays. We applied the method to assess the fitness …
insertional mutagenesis and DNA microarrays. We applied the method to assess the fitness …
Highly parallel assays of tissue-specific enhancers in whole Drosophila embryos
Transcriptional enhancers are a primary mechanism by which tissue-specific gene
expression is achieved. Despite the importance of these regulatory elements in development, …
expression is achieved. Despite the importance of these regulatory elements in development, …
The whole genome sequences and experimentally phased haplotypes of over 100 personal genomes
Background Since the completion of the Human Genome Project in 2003, it is estimated that
more than 200,000 individual whole human genomes have been sequenced. A stunning …
more than 200,000 individual whole human genomes have been sequenced. A stunning …
A new method for valuing common stocks
PW Estep - Financial Analysts Journal, 1985 - Taylor & Francis
A new formula for estimating an investor's expected return-the T-Model-expresses total return
in terms of a company's growth rate, its return on equity and its price-book ratio. The model …
in terms of a company's growth rate, its return on equity and its price-book ratio. The model …
Transparency is key to ethical vaccine research
The Rapid Deployment Vaccine Collaborative (RaDVaC) is a free and open-source project
that designs, tests, and shares vaccine designs and protocols. In their Policy Forum “…
that designs, tests, and shares vaccine designs and protocols. In their Policy Forum “…