Science, sentience, and animal welfare

RC Jones - Biology & philosophy, 2013 - Springer
I sketch briefly some of the more influential theories concerned with the moral status of
nonhuman animals, highlighting their biological/physiological aspects. I then survey the most …

Benchmarking single-cell RNA-sequencing protocols for cell atlas projects

…, JK Lau, SC Boutet, C Sanada, A Ooi, RC Jones… - Nature …, 2020 - nature.com
Single-cell RNA sequencing (scRNA-seq) is the leading technique for characterizing the
transcriptomes of individual cells in a sample. The latest protocols are scalable to thousands of …

[HTML][HTML] High-throughput single nucleotide polymorphism genotyping using nanofluidic Dynamic Arrays

…, WY Huang, RB Hayes, SJ Chanock, RC Jones… - BMC genomics, 2009 - Springer
Background Single nucleotide polymorphisms (SNPs) have emerged as the genetic marker
of choice for mapping disease loci and candidate gene association studies, because of their …

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

The Tabula Sapiens Consortium*, RC Jones… - Science, 2022 - science.org
Molecular characterization of cell types using single-cell transcriptome sequencing is
revolutionizing cell biology and enabling new insights into the physiology of human organs. We …

Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly

…, J Leskovec, CN McLaughlin, Q Xie, RC Jones… - Science, 2022 - science.org
For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most
studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula …

Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex

…, DW Kemp, M Wong, B Clerkson, BN Jones… - Nature …, 2014 - nature.com
Large-scale surveys of single-cell gene expression have the potential to reveal rare cell
populations and lineage relationships but require efficient methods for cell capture and mRNA …

[HTML][HTML] High throughput gene expression measurement with real time PCR in a microfluidic dynamic array

SL Spurgeon, RC Jones, R Ramakrishnan - PloS one, 2008 - journals.plos.org
We describe a high throughput gene expression platform based on microfluidic dynamic
arrays. This system allows 2,304 simultaneous real time PCR gene expression measurements …

Taking qPCR to a higher level: Analysis of CNV reveals the power of high throughput qPCR to enhance quantitative resolution

…, A Mir, J Qin, G Sun, R Ramakrishnan, RC Jones… - Methods, 2010 - Elsevier
This paper assesses the quantitative resolution of qPCR using copy number variation (CNV)
as a paradigm. An error model is developed for real-time qPCR data showing how the …

Habitat value of bivalve shellfish and seaweed aquaculture for fish and invertebrates: Pathways, synthesis and next steps

…, BA Costa‐Pierce, A St. Gelais, RC Jones - Reviews in …, 2022 - Wiley Online Library
Aquaculture can have negative environmental impacts, adding to the suite of anthropogenic
stressors that challenge coastal ecosystems. However, a growing body of scientific …

Impact of worksite health promotion on health care costs and utilization: evaluation of Johnson & Johnson's Live for Life program

JL Bly, RC Jones, JE Richardson - Jama, 1986 - jamanetwork.com
This study explores the relationship between exposure to a comprehensive worksite health
promotion program and health care costs and utilization. The experience of two groups of …