Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids

N Zaidi, L Lupien, NB Kuemmerle, WB Kinlaw… - Progress in lipid …, 2013 - Elsevier
One of the most important metabolic hallmarks of cancer cells is enhanced lipogenesis.
Depending on the tumor type, tumor cells synthesize up to 95% of saturated and mono-…

Abnormal zinc metabolism in type II diabetes mellitus

WB Kinlaw, AS Levine, JE Morley, SE Silvis… - The American journal of …, 1983 - Elsevier
Zinc metabolism in 20 patients with stable type II diabetes mellitus was investigated. Twenty-five
percent of these patients had depressed serum zinc concentrations, and all …

[HTML][HTML] Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention

…, V de Laat, A Talebi, M Loda, WB Kinlaw… - Advanced drug delivery …, 2020 - Elsevier
With the advent of effective tools to study lipids, including mass spectrometry-based lipidomics,
lipids are emerging as central players in cancer biology. Lipids function as essential …

Impotence in medical clinic outpatients

…, DL Trence, CJ Nelson, AE Nelson, WB Kinlaw… - Jama, 1983 - jamanetwork.com
One thousand one hundred eighty men in a medical outpatient clinic were screened as to
the presence of impotence. Four hundred one men (34%) were impotent, and of those, 188 (47…

Lipoprotein lipase links dietary fat to solid tumor cell proliferation

…, BL Eisenberg, WB Coleman, WB Kinlaw - Molecular cancer …, 2011 - AACR
Many types of cancer cells require a supply of fatty acids (FA) for growth and survival, and
interrupting de novo FA synthesis in model systems causes potent anticancer effects. We …

[PDF][PDF] CD36-mediated metabolic rewiring of breast cancer cells promotes resistance to HER2-targeted therapies

…, L Pusztai, M Febbraio, C Cheng, WB Kinlaw… - Cell reports, 2019 - cell.com
Although it is established that fatty acid (FA) synthesis supports anabolic growth in cancer,
the role of exogenous FA uptake remains elusive. Here we show that, during acquisition of …

Long-term response of pituitary carcinoma to temozolomide: report of two cases

…, LP Meyer, LS Kingman, WB Kinlaw… - Journal of …, 2006 - thejns.org
✓Pituitary carcinoma is a rare tumor characterized by poor responsiveness to therapy, leading
to early death. Reported responses to standard chemotherapy have only been anecdotal, …

Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1

…, CS Ringelberg, B Gimi, WB Kinlaw III… - Toxicology and applied …, 2016 - Elsevier
Obesity is an increasingly urgent global problem, yet, little is known about its causes and
less is known how obesity can be effectively treated. We showed previously that the aryl …

[HTML][HTML] Direct evidence for a role of the “spot 14” protein in the regulation of lipid synthesis

WB Kinlaw, JL Church, J Harmon… - Journal of Biological …, 1995 - ASBMB
"Spot 14" is a nuclear protein that is rapidly induced by thyroid hormone (T 3 ) and dietary
carbohydrate in liver. We used an antisense oligonucleotide to inhibit induction of spot 14 …

AMPK Activation by Metformin Promotes Survival of Dormant ER+ Breast Cancer Cells

…, YH Huang, JD Marotti, AE Goen, WB Kinlaw… - Clinical Cancer …, 2020 - AACR
Purpose: Despite adjuvant endocrine therapy for patients with estrogen receptor alpha (ER)-positive
breast cancer, dormant residual disease can persist for years and eventually cause …